The Food and Drug Administration (FDA) has designated the chemical fucoidan as a food additive in the Generally Recognized As Safe (GRAS) category since it is non-toxic, biodegradable, and biocompatible.
In contrast, Wilfred et al. found in a different study that fucoidan, at a dose of 700 g/mL, can prevent 50% of cancer cell multiplication after 48 hours [23]. The difference could mostly be attributed to different fucoidan sources.
According to our findings, fucoidan boosted nitric oxide synthesis via phosphorylating Akt and eNOS, which might be hindered by Akt or eNOS inhibitors. Treatment with fucoidan led to a significant and long-lasting decrease in high blood pressure (BP) in the hypertensive rat model, even after the drug was stopped.
The liver damage brought on by TAA was lessened by the use of fucoidan, which was able to decrease the inflammation and variables connected to liver damage. The development of liver damage and its pathophysiology are significantly influenced by oxidative stress.
Fucoidan and marine polyphenols have been shown in published research to have a variety of benefits for maintaining and growing hair, opening up new opportunities for cosmetic and personal care products.
The two most prized seaweed species from which Fucoidans are produced and which are significant in many clinical trials are Undaria pinnatifida and Fucus vesiculosus.
Fucoidan can lessen oxidative stress, edema, and inflammation associated with arthritis, according to a 2017 study. Fucoidan was proven to be effective against synovial fibrosis in a 2022 trial. In many medical disorders, this causes stiffness and joint pain.
Consequently, fucoidan offers promising application prospects for the treatment of cardiovascular illnesses as an anticoagulant and antithrombotic medication with fewer adverse effects.
By preventing microglial activation, fucoidan lowers inflammatory responses in brain illnesses. As a result, neuronal and astrocyte degeneration is considerably reduced as a result of decreased pro-apoptotic agent production and improved antioxidant responses of the cell.
Fucoidan aids in weight loss and the treatment of metabolic syndrome.Fucoidan has been proven to increase anti-diabetic activities, such as lowering high blood sugars and assisting the body in properly using insulin, as well as aid in fat cell breakdown, better digestion, immunity, and immunity.